Bug #25 Added by Padraig Gleeson almost 6 years ago. Updated almost 6 years ago.

Is the "f" rate variable in the calcium channel really inactivation?

Status:
New
Priority:
Normal
Assignee:
-
Start date:
17 Oct 2012
Due date:
% Done:

0%


Description

See comments in http://www.opensourcebrain.org/projects/muscle_model/repository/revisions/master/entry/NeuroML2/ca_boyle.nml.

The parameters in the paper suggest this is an activation variable, and since it's very slow (tau=151ms) it will mean the channel will hardly ever open...

History

#1 Updated by Mike Vella almost 6 years ago

Padraig Gleeson wrote:

See comments in http://www.opensourcebrain.org/projects/muscle_model/repository/revisions/master/entry/NeuroML2/ca_boyle.nml.

The parameters in the paper suggest this is an activation variable, and since it's very slow (tau=151ms) it will mean the channel will hardly ever open...

In the title I think you mean "f" is activation not inactivation? I agree with you on this point. There is something very perplexing here, The activation rate would be too slow to support the kind of regular spiking we see in the data. Could this be a typo in the paper? I haven't looked at the c++ code.